Introduction and application of  CAS No. 317-34-0 | Aminophylline

Synonyms:Theophylline-ethylenediaMineanhydrousCOS;

(Theophylline)2Ethylenediamine,Theophyllinehemiethylenediaminecomplex,3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione,cmpd.with1,2-ethanediamine(2:1);

Aminophylline,99%;

Theophylline-e;

Aminophyllinehydrat;

AMINOPHYLLINE;

THEOPHYLLINECOMPOUNDWITHETHYLENEDIAMINE

Specification:

Overview:

Aminophylline is a double salt composed of theophylline and ethylenediamine. It belongs to the xanthine class of drugs. Its pharmacological effects are mainly derived from theophylline. Theophylline has the strongest effect on relaxing airway smooth muscles among the xanthine alkaloid drugs. B Diamine can enhance its water solubility. Aminophylline is suitable for the treatment of bronchial asthma, obstructive emphysema and wheezing bronchitis. It can not only relax bronchial smooth muscle, but also have cardiotonic, diuretic, coronary dilation, anti-inflammatory, antagonize adenosine receptors, immune regulation, etc., so it can also be used to treat diseases such as premature infant asphyxia, sick sinus syndrome, acute lung injury, etc.

Pharmacological effects

1. Relax airway smooth muscle: Aminophylline can relax airway smooth muscle and relieve bronchospasm.

2. Immune regulation and anti-inflammatory effects: A small amount of aminophylline can inhibit the release of inflammatory transmitters by mast cells and relieve airway smooth muscle spasm; it can also inhibit eosinophil infiltration in the bronchus.

3. Enhance respiratory muscle contractility: Prevent and treat diaphragm fatigue and respiratory failure by improving respiratory function.

4. Exciting the respiratory center: Exciting breathing and enhancing the depth of breathing, but the breathing frequency does not increase.

5. Cardiotonic: Acts on the heart, antagonizes adenosine, prevents excessive release of adenosine, expands coronary arteries and peripheral blood vessels, promotes myocardial contraction, and increases cardiac output.

6. Diuresis: Increase renal blood flow and glomerular filtration rate, and inhibit renal tubular reabsorption.

Chemical properties:

White or light yellow granules or powder. Melting point 269-274℃. Easily soluble in water, insoluble in ethanol or ether. Exposure to the air gradually absorbs carbon dioxide gas and decomposes or theophylline. It has a slight odor and a bitter taste.

use:

The functions and uses of this product are the same as those of theophylline. The presence of ethylenediamine in the molecule enhances the dilation of bronchial and coronary vessels. It is mainly used for bronchial asthma and asthmatic chronic bronchitis. It can also be used as a non-selective phosphodiesterase inhibitor (phosphodiesterase, PDE) and anti-epileptic drug for acute cardiac insufficiency, cardiac asthma and biliary colic.

production method:

This product is a compound salt of theophylline and ethylenediamine. Put theophylline into the mixer, stir and cool, use compressed air to spray into the mixture of newly distilled ethylenediamine and distilled water, after spraying, continue stirring for 10 minutes to obtain aminophylline.

Package and transportation :

Package: 10g,25g,50g,100g,250g

Transportation: by courier/ by air/ by sea